Therapeutic advances in non-small cell lung cancer
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چکیده
Commun Oncol 2011;8(suppl 1):5–16 © 2011 Elsevier Inc. All rights reserved. A n efficacy plateau has been reached with conventional platinum-based doublet chemotherapy regimens as first-line treatment for advanced non-small cell lung cancer (NSCLC),1 underscoring the need for new strategies. Over the past decade, several therapeutic options for relapsed NSCLC were introduced. New agents include the novel antifolate pemetrexed and the molecularly targeted agents bevacizumab and erlotinib.2 This article reviews lessons learned from randomized trials regarding the optimal use of these newer agents as first-line therapy and maintenance therapy. Based on these data, since published, ongoing trials are further evaluating the optimal use of these and other promising agents in the management of patients with advanced NSCLC.
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